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Current evidence suggests that silymarin is safe for. The data presented on efficacy and safety of silymarin may provide more foundation for further trials and for a possible use in clinical practice According to the findings of clinical trials, silymarin is safe in humans at higher doses (over 1,500 mg/day) and no serious side effects have been reported [37].

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Silymarin, during clinical trials, shows potential improvements in liver function, reduced mortality rates, and alleviation of symptoms across various liver disorders, with safety assessments. Regular monitoring and consultation with healthcare. The cornerstone for treating fatty liver disease is lifestyle modification, diet, exercise, and behavioral therapy, along with the limited use of pharmacological agents

Silymarin is a complex mixture of 6 major flavonolignans and other minor polyphenolic compounds derived from the milk thistle plant silybum marianum

The present trial aims to assess the efficacy of silymarin supplementation in the adjuvant treatment of nafld in adult patients